| Adobe Acrobat Reader DC | PDF Viewer | Office and Productivity | Mac, Windows | Free | |
| Alertus Desktop Notification | Emergency Alerts and Notification System | Security | Mac, Windows | University Licensed | |
| AutoDesk | Design and Drafting Software used by architects, designers, and planners. | Design & Drafting | Mac, Windows | University Licensed | |
| Banner Admin Production | Allows authorized users to perform various administrative actions pertaining to finance, financial aid, HR, and obtaining student information. | Office and Productivity | Mac, Windows | University Licensed | |
| BlackBaud CRM (WREN) | Donorship and Fundraising | Fundraising | Web App | University Licensed | |
| Box | File Sharing and Storage | File Sharing | Web App | University Licensed | |
| Box Drive | Add-on to Box which allows access through Windows Explorer or Mac Finder | File Sharing | Mac, Windows | Free | |
| Chem BioDraw Ultra | Chemical Structures Drawing Software | Chemistry | Mac, Windows | University Licensed | |
| DUO Mobile | Two factor authentication (2F) software that runs on your PC, phone, or mobile device | Security | Mobile | University Licensed | |
| Eduroam | William & Mary's secure wireless network | Security & Networking | Mac, Windows, Mobile | University Licensed | |
| Geospatial Analysis/GIS | Geospatial Analysis (GIS) | Design/Analysis | Web App | University Licensed | |
| Global Protect for MacOs | Complete infrastructure for managing your mobile workforce to enable secure access for all your users, regardless of what devices they are using or where they are located. | Security & Networking | Mac | University Licensed | |
| Global Protect (VPN) for Windows | Complete infrastructure for managing your mobile workforce to enable secure access for all your users, regardless of what devices they are using or where they are located. | Security & Networking | Windows | University Licensed | |
| Google Chrome | A cross-platform web browser by Google | Internet and Email | Mac, Windows | Free | |
| LinkedIn Learning | Online education and training platform. | Training | Web App | University Licensed | |
| Maple | Math & Statistical Problem Solving Tool | Math & Statistics | Linux, Mac, Windows | University Licensed | |
| Matlab | MATLAB is a high-level language and interactive environment that enables you to perform computational and visualization intensive tasks. | Statistics | Windows | University Licensed | |
| MAXQDA | Qualitative Analysis and Research Tool | Qualitative Analysis Tools | Mac, Windows | University Licensed | |
| Microsoft Office 365 | Suite of cloud-based productivity and collaboration applications that integrates all Microsoft's existing online applications (Word, Excel, PowerPoint, OneNote, Outlook, Publisher, Sway, and Access) into a cloud service | Office and Productivity | Mac, Windows | University Licensed | |
| Microsoft Teams | Chat and Collaboration | Office Productivity | Windows, macOS, Linux, Mobile | University Licensed | |
| Minitab for Mac | Minitab is a statistics package | Statistics | Mac | University Licensed | |
| Minitab for Windows | Minitab is a statistics package | Statistics | Windows | Subscription Fees | |
| Mitel Connect for Mac | Interface that extends the features of you campus phone | Office and Productivity | Mac | University Licensed | |
| Mitel Connect for Windows | Interface that extends the features of you campus phone | Office and Productivity | Windows | University Licensed | |
| Mozilla Firefox Mac | A cross-platform web browser by Mozilla | Internet and Email | Mac | Free | |
| Mozilla Firefox Windows | A cross-platform web browser by Mozilla | Internet and Email | Windows | Free | |
| Panopto | Video capturing software integrated into Blackboard | Classroom Support | Mac, Mobile, Windows
| University Licensed | |
| PCModel | Chemistry Molecular Modelling | Chemistry | Mac, Windows | University Licensed | |
| Poly Lens | Poly Headset Software | Office/Hardware | Windows, Mac | No special license needed | |
| SAS | Statistical Analytics, Artificial Intelligence and Data Management Software | Math & Statistics | Linux, Mac, Windows | University Licensed | |
| SPSS | Statistical Package for the Social Sciences | Math & Statistics | Mac, Windows | University Licensed | |
| Stata | General purpose Statistical Software | Statistics | Windows | Subscription Fees | |
| Wolfram Mathematica | Math, Statistical and Computational Software | Math, Statistics, and Computational Software | Unix, Linux, Mac, Windows | University Licensed | |
| Zoom | Cloud-based video communications app that allows you to set up virtual video and audio conferencing, webinars, live chats, screen-sharing, and other collaborative capabilities | Office and Productivity, Teaching and Learning | Mac, Windows | University Licensed | |
